Women who have premature ovarian failure - also known as primary ovarian insufficiency - might have irregular or occasional periods for years. Premature ovarian failure refers to the loss of normal ovarian function before age 40. Women with this common endocrine system disorder may have irregular periods as well as enlarged ovaries that contain small collections of fluid - called follicles - located in each ovary as seen during an ultrasound exam. Eating disorders - such as anorexia nervosa - extreme weight loss and increased physical activity can disrupt menstruation. Eating disorders, extreme weight loss or excessive exercising.Breast-feeding typically delays the return of menstruation after pregnancy. A missed period can be an early sign of pregnancy. Menstrual cycle irregularities can have many different causes, including:
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